All-or-none cell shortening of isolated single smooth muscle cells to acetylcholine and Ca2+ sensitization.
نویسندگان
چکیده
منابع مشابه
Expression of smooth muscle myosin heavy chains and unloaded shortening in single smooth muscle cells.
The functional significance of the variable expression of the smooth muscle myosin heavy chain (SM-MHC) tail isoforms, SM1 and SM2, was examined at the mRNA level (which correlates with the protein level) in individual permeabilized rabbit arterial smooth muscle cells (SMCs). The length of untethered single permeabilized SMCs was monitored during unloaded shortening in response to increased Ca2...
متن کاملGraded and All-or-None Electrogenesis in Arthropod Muscle
Graded electrically excited responsiveness of Romalea muscle fibers is converted to all-or-none activity by Ba(++), Sr(++), or Ca(++), the two former being much the more effective in this action. The change occurs with as little as 7 to 10 per cent of Na(+) substituted by Ba(++). The spikes now produced have overshoots and may be extremely prolonged, lasting many seconds. During the spike the m...
متن کاملCa2+ sensitization of smooth muscle contractility induced by ruthenium red.
The effects of ruthenium red (RuR) on contractility were examined in skinned fibers of guinea pig smooth muscles, where sarcoplasmic reticulum function was destroyed by treatment with A-23187. Contractions of skinned fibers of the urinary bladder were enhanced by RuR in a concentration-dependent manner (EC50 = 60 μM at pCa 6.0). The magnitude of contraction at pCa 6.0 was increased to 320% of c...
متن کاملDistribution of alpha-actinin in single isolated smooth muscle cells
In order to probe the organization of the contractile machinery in smooth muscle, we have studied the distribution of alpha-actinin, a protein present in high concentration in dense bodies, structures apparently analogous to the Z-disks of striated muscle. Localization of alpha-actinin in single isolated smooth muscle cells of the stomach muscularis of Bufo marinus was determined by analysis of...
متن کاملDistribution of a-Actinin in Single Isolated Muscle Cells Smooth
In order to probe the organization of the contractile machinery in smooth muscle, we have studied the distribution of a-actinin, a protein present in high concentration in dense bodies, structures apparently analogous to the Z-disks of striated muscle. Localization of aactinin in single isolated smooth muscle cells ofthe stomach muscularis of Bufo marinus was determined by analysis of the patte...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1994
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)50477-2